Hypertension in agouti obese mice is not due to sympathetic activation
نویسندگان
چکیده
منابع مشابه
Hypertension in Obese Black Women is Not Caused by Increased Sympathetic Vascular Tone
BACKGROUND Black women have one of the highest prevalence rates of hypertension and obesity in the United States. We previously reported that sympathetic activation induced by obesity is a significant contributor to hypertension in white patients. It is unknown whether sympathetic activity similarly contributes to hypertension in obese black women. METHODS AND RESULTS We studied 42 obese wome...
متن کاملSubcutaneous obesity is not associated with sympathetic neural activation.
We tested the hypothesis that muscle sympathetic nerve activity (MSNA) would not differ in subcutaneously obese (SUBOB) and nonobese (NO) men with similar levels of abdominal visceral fat despite higher plasma leptin concentrations in the former. We further hypothesized that abdominal visceral fat would be the strongest body composition- or regional fat distribution-related correlate of MSNA am...
متن کاملSelective resistance to central neural administration of leptin in agouti obese mice.
We recently demonstrated that in a rodent model of obesity (agouti yellow mice), there is a selective leptin resistance with preservation of the sympathetic actions despite loss of appetite and weight-reducing actions of systemic leptin. Here, we examined whether selective leptin resistance exists in agouti mice during central neural administration of leptin. In agouti obese mice and lean contr...
متن کاملPoint: Chronic activation of the sympathetic nervous system is the dominant contributor to systemic hypertension.
TO THE EDITOR: I thank my friends, colleagues, and opponents for their thoughtful submissions (see Ref. 1), which capture the diversity of views concerning the pathophysiological mechanisms of essential hypertension. Many seem to have lodged an each-way bet, invoking parallel sympathetic nervous system and renin-angiotensin system origins. A few seemed to think the question was a silly one and ...
متن کاملp53 Activation in adipocytes of obese mice.
The tumor suppressor p53 is a transcription factor that activates or represses its target genes after various genotoxic stresses. We have previously shown that sterol regulatory element-binding protein-1 (SREBP-1), a key transcriptional regulator of triglyceride synthesis, and the lipogenic enzymes under its control are markedly suppressed in adipocytes from genetically obese ob/ob mice. Here w...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Hypertension
سال: 2000
ISSN: 0895-7061
DOI: 10.1016/s0895-7061(00)00318-6